On the surface it is pretty simple; you have to adjust in an exploitative manner preflop by not playing like everyone else at the table. In general, most players will play WAY too many hands in live PLO settings, so you have to adjust by folding some of the speculative combos preflop. Focus on playing combos that have a lot of nuttiness and absolute hand strength such as large pairs with either nutty suits and/or nutty connectedness, large double suited connected combos and very connected high ranking single suited rundowns. This type of range will set you up for postflop success in multiway pots where you will flop nutty types of made hands and draws helping you avoid tough spots!
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