Blockers Matter More When Your Opponent's Range is Not Capped
Everyone talks about blockers in PLO and they are very often important, but blocking nutty combos when bluffing really only matters if your opponent can actually have the nuts in his range. If his range is capped for whatever reason you don't have to necessarily block nutty combos to consider bluffing him. Consider bluffing even more often without blockers in those spots to exploit him!